Xeroderma
Pigmentosum
Xeroderma
Pigmentosum is a rare genetic defect in which the skin and tissue covering the
eye are extremely sensitive to ultraviolet rays from sunlight. It is caused by
the defect in Nucleotide Excision Repair (NER) which leads to deficient repair
of DNA damaged by UV radiation. It is usually detected early in infancy around 6 months after birth.
Symptoms-
It
includes, blistering and sunburn after a bit of sun exposure, scaling,
freckling & crusting of the skin, premature skin aging, skin cancer.
Treatment –
Children are kept away from sunlight and even
lights from fluorescent bulbs, wear UV protected sunglasses, and apply high SPF
(greater than 70) cream, wear protective clothing and doctor’s prescription
medicine to prevent growth of skin cancers.
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