Paroxysmal nocturnal hemoglobinuria
Formerly
Marchiafava–Micheli disease is an occasional, hereditary developed,
life-threatening sickness of the blood categorized by obliteration of red blood
cells by the accompaniment system, a part of the body's inherent immune system.
Symptoms
The
definitive sign of PNH is red staining of the urine due to the attendance of
hemosiderin and hemoglobin from the failure of red blood cells.
Diagnosis
Blood tests
in PNH show vicissitudes reliable with intravascular hemolytic anemia: low
hemoglobin, raised lactate dehydrogenase, raised bilirubin (a breakdown product
of hemoglobin), and decreased levels of haptoglobin.
Treatment
Transfusion
therapy may be needed, in adding to modifying important anemia, this overpowers
the making of PNH cells by the bone marrow.
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